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Pharmacology: Pharmacodynamics: Gliclazide stimulates the secretion of insulin from functioning pancreatic islet B-cells. In addition to this pancreatic action, it has been demonstrated that Gliclazide administration may improve the metabolic utilization of glucose at a peripheral level.
Pharmacokinetics: Gliclazide is readily absorbed from the gastrointestinal tract. It is extensively bound to plasma proteins. The half-life is about 10 to 12 hours. Gliclazide is extensively metabolised in the liver to metabolites that have no significant hypoglycaemic activity. Metabolites and a small amount of unchanged drug are excreted in the urine.
